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Drugs with a Vd value of less than 0.3 L/kg are predominantly confined to the ECF, whereas drugs with a Vd value of greater than 1 L/kg are highly lipid soluble and tend to distribute out of the extracellular fluid and into tissue compartments (Box 4-1)

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Studies show: 14.9% mean weight loss vs 2.4% (~6 lb) weight loss with placebo at 68 weeks with Semaglutide 25% mean weight loss with Tirzepatide If you have diabetes, please get this medication through your primary care providers

Most patients notice reduced appetite within 24 weeks of starting semaglutide, with measurable weight loss appearing by week 46

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It has to be underlined that, while current evidence of GLP-1RAs efficacy on PsD-related comorbidities relies on solid systematic reviews, RCTs, and large cohort studies, their potential role in rheumatologic disorders, particularly in PsD, remains largely unexplored